The answer is no.
If a value other than the specified one is set to an internal peripheral register (SFR), normal operation may not be possible.
This is because, in addition to the disclosed functions (which have been tested and whose operation is guaranteed), the internal peripheral functions include also undisclosed functions (which have not been tested and whose operation is not guaranteed). Moreover, in some cases, some functions are included for device testing purposes, and if values other than specified ones are set to these registers, malfunction may result.
Basically, the operation of a microcontroller is guaranteed only under the conditions specified in the manual for that microcontroller. Therefore, settings other than the specified ones must not be done.